Lithium may decrease risk of developing dementia: Study | Fitness News

Lithium may decrease risk of developing dementia: Study | Fitness News

Cambridge: A brand new analysis led by the University of Cambridge, have recognized a hyperlink suggesting that lithium might decrease the risk of developing dementia. The analysis was printed within the journal, ‘PLoS Medicine.’ The analysis performed a retrospective evaluation of the well being data of practically 30,000 sufferers from Cambridgeshire and Peterborough NHS Foundation Trust.
The sufferers had been all around the age of 50 and accessed NHS psychological well being companies between 2005 and 2019. The evaluation instructed that sufferers who obtained lithium had been much less more likely to develop dementia than those that didn’t, though the general quantity of sufferers who obtained lithium was small. It additionally instructed that lithium may very well be a preventative remedy for dementia and may very well be progressed to massive randomised managed trials.
Dementia is the main trigger of loss of life in aged Western populations, however no preventative remedies are at the moment accessible. More than 55 million folks worldwide have dementia, with Alzheimer’s illness the commonest type.
“The quantity of folks with dementia continues to develop, which places large stress on healthcare methods,” mentioned Dr Shanquan Chen from Cambridge’s Department of Psychiatry, the paper’s first creator.
“It’s been estimated that delaying the onset of dementia by simply 5 years might cut back its prevalence and financial affect by as a lot as 40 p.c,” he added.
Previous research have proposed lithium as a possible remedy for individuals who have already been identified with dementia or early cognitive impairment, however it’s unclear whether or not it could possibly delay and even stop the event of dementia altogether, as these research have been restricted in dimension.
Lithium is a temper stabiliser normally prescribed for circumstances equivalent to bipolar affective dysfunction and melancholy.
“Bipolar dysfunction and melancholy are thought of to place folks at elevated risk of dementia, so we had to verify to account for this in our evaluation,” mentioned Chen.
Chen and his colleagues analysed knowledge from sufferers who accessed psychological well being companies from Cambridgeshire and Peterborough NHS Foundation Trust between 2005 and 2019.
Patients had been throughout 50 years of age, obtained at the least a one-year follow-up appointment, and had not been beforehand identified with both gentle cognitive impairment or dementia.
Of the 29,618 sufferers within the examine cohort, 548 sufferers had been handled with lithium and 29,070 had not. Their imply age was slightly below 74 years, and roughly 40 p.c of sufferers had been male. For the group that had obtained lithium, 53, or 9.7 per cent had been identified with dementia.
For the group that had not obtained lithium, 3,244, or 11.2 per cent, had been identified with dementia.
After controlling for components equivalent to smoking, different drugs, and different bodily and psychological sicknesses, lithium use was related to a decrease risk of dementia, each for brief and long-term customers.
However, because the general quantity of sufferers receiving lithium was small and this was an observational examine, bigger scientific trials can be wanted to ascertain lithium as a possible remedy for dementia.
Another limitation of the examine was the quantity of sufferers who had been identified with bipolar dysfunction, which is generally related to an elevated risk of dementia.
“We anticipated to search out that sufferers with bipolar dysfunction had been extra more likely to develop dementia since that’s the commonest cause to be prescribed lithium, however our evaluation instructed the other,” mentioned Chen.
“It’s far too early to say for positive, but it surely`s attainable that lithium would possibly cut back the risk of dementia in folks with bipolar dysfunction,” he concluded.
 

https://zeenews.india.com/health/lithium-may-decrease-risk-of-developing-dementia-study-2446794

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