RSV Prefusion F Protein-Based Immunization Studied in Pregnancy – Consumer Health News

WEDNESDAY, April 27, 2022 (HealthDay News) — A bivalent respiratory syncytial virus (RSV) prefusion F protein-based mostly (RSVpreF) vaccine given throughout being pregnant elicits neutralizing antibody responses, in response to a research revealed in the April 28 situation of the New England Journal of Medicine.Eric A.F. Simões, M.D., from the University of Colorado School of Medicine in Aurora, and colleagues randomly assigned pregnant girls at 24 by means of 36 weeks of gestation to obtain 120 or 240 μg of RSVpreF vaccine (with or with out aluminum hydroxide) or placebo in a section 2b trial.Four hundred and 6 girls and 403 infants had been included in the deliberate interim evaluation; 80.5 p.c of girls acquired RSVpreF vaccine. The researchers discovered that almost all postvaccination reactions had been delicate to reasonable; girls who acquired RSVpreF vaccine containing aluminum hydroxide had the next incidence of native reactions than those that acquired RSVpreF vaccine with out aluminum hydroxide. For girls and infants, the incidences of hostile occasions had been comparable in the vaccine and placebo teams; the sort and frequency of occasions had been in step with the background incidences. The geometric imply ratios of fifty p.c neutralizing titers between the infants of vaccine versus placebo recipients ranged from 9.7 to 11.7 and from 13.6 to 16.8 amongst these with RSV A and RSV B neutralizing antibodies, respectively. There was variation from 1.41 to 2.10 in transplacental neutralizing antibody switch ratios, and these ratios had been increased for nonaluminum than aluminum formulations.”Our trial additionally confirmed preliminary proof of the efficacy of maternal vaccination with RSVpreF vaccine throughout being pregnant in stopping RSV-associated decrease respiratory tract sickness in infants,” the authors write.The research was funded by Pfizer.Abstract/Full Text (subscription or cost could also be required)

Recommended For You