Clinical trial investigating CBD for opioid addiction gets underway

The first affected person has been enrolled in a scientific trial investigating whether or not CBD could possibly be an efficient therapy for opioid use dysfunction.Pharmaceutical firm, Ananda Scientific, has introduced {that a} scientific trial exploring using CBD as a therapy for opioid use dysfunction, is now underway marking a “key milestone” for the corporate.The randomised, double-blind, placebo managed examine, which is funded by the National Institute on Drug Abuse (NIDA) within the US, will consider the effectiveness of Ananda’s proprietary CBD system, generally known as Nantheia™ ATL5. Participants will likely be given cannabidiol (CBD) at doses of 600 and 1200 mg/day as an adjunctive remedy to buprenorphine and naloxone, whereas additionally receiving residential behavioural remedy, together with cognitive behavioural remedy for opioid use dysfunction. Opioids are generally used for the therapy of ache, and embody medicines corresponding to morphine, fentanyl and tramadol, however extended use, misuse and use with out medical supervision can result in opioid dependence and different well being issues.According to the World Health Organisation half one million deaths worldwide are attributable to drug use, with greater than 70 per cent of these associated to opioids.While CBD and medical hashish are sometimes used instead therapy to opioids for managing circumstances corresponding to persistent ache, a lot much less is understood about their potential for treating addiction.  The important goal of the trial will likely be to evaluate the protection and tolerability of CBD in these sufferers, with secondary measures together with cue-induced craving, reductions in spontaneous craving, opioid withdrawal, damaging affective states, and relapse, in addition to retention in therapy with buprenorphine and naloxone.The trial is being led by principal investigators Distinguished Professor Edythe London, PhD and Professor Richard De La Garza II, PhD of Psychiatry and Biobehavioural Sciences on the Semel Institute, Geffen School of Medicine, UCLA.“The first affected person enrolled on this examine is a key milestone for our ongoing analysis into therapeutic options for opioid use dysfunction,” Dr London commented.“Bridging psychiatry, pharmacology and neuroscience, we wish to develop evidence-based therapies for addiction.”Dr De La Garza added: “We are excited to be transferring this trial ahead after finishing all of the preparatory work. We hope this scientific trial will reply vital questions concerning the potential of cannabidiol within the therapy of opioid addiction.”Sohail R Zaidi, Ananda’s Chief Executive Officer (CEO) mentioned: “We are delighted to have the primary affected person enrolled on this vital trial of our investigational drug Nantheia™ ATL5. This scientific examine is a vital element of our scientific improvement efforts targeted on opioid addiction, the place non-addictive remedy is a major unmet want.“We are impressed by the scientific competence and operational diligence of the scientific trial group at UCLA which makes them our associate of selection for future trials as we develop the scientific programme.”Home » Industry » Clinical trial investigating CBD for opioid addiction gets underway

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