Body Mass Index Tied to Multiple Myeloma Survival – Consumer Health News

FRIDAY, Jan. 20, 2023 (HealthDay News) — Underweight and extreme weight problems are related to decreased survival in sufferers with a number of myeloma (MM), in accordance to a examine revealed on-line Jan. 12 within the Blood Cancer Journal.Urvi A. Shah, M.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues assessed the affect of physique mass index (BMI) on development-free survival (PFS) and general survival (OS) in sufferers with newly identified MM. The evaluation included knowledge from 1,142 sufferers from the Multiple Myeloma Research Foundation CoMMpass registry.The researchers discovered that each sufferers with underweight and extreme weight problems had decrease median PFS and OS than sufferers with regular weight, obese, and reasonable weight problems. Patients with underweight had a considerably larger danger for dying in fashions associating PFS and OS with BMI (hazard ratio [HR], 2.32; 95 p.c confidence interval [CI], 1.09 to 4.97). Patients with extreme weight problems tended to have the next for danger of development (HR, 1.29; 95 p.c CI, 0.99 to 1.67) and dying (HR, 1.43; 95 p.c CI, 0.98 to 2.08) versus sufferers with regular BMI. OS worsened with larger comorbidities (three-12 months OS for Charlson Comorbidity Index [CCI] ≥5: 65 p.c; CCI >2 to <5: 87 p.c; CCI ≤2: 87 p.c). Frailty was additionally considerably related to worse OS (three-12 months OS for frail versus nonfrail: 70 versus 88 p.c). When accounting for CCI, there was a pattern towards decreased OS within the underweight group versus the conventional-weight group (HR, 2.12; 95 p.c CI, 0.99 to 4.53)."Clinical analysis to perceive if sufferers with excessive BMI could profit from weight administration methods to enhance outcomes could also be of significance," the authors writeAbstract/Full Text

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