One Surprising Side Effect of Cutting Calories, New Study Finds

For many individuals making an attempt to drop extra pounds, counting—and slicing—energy is a tried-and-true technique of shedding kilos with out having to stick to a specialised food regimen. However, new analysis means that it is not simply your weight that will change while you stick with a calorie-restricted consuming plan.
According to a June 2021 research printed within the journal Nature, calorie restriction can have a big impact on an individual’s intestine microbiome, as nicely. To conduct their research, a bunch led by researchers from the University of California San Francisco (UCSF) monitored a bunch of 80 chubby and overweight girls over a 16-week interval. During this time, half of the research inhabitants went on a liquid food regimen consisting of 800 energy a day, whereas the opposite half of the research topics maintained their weight.

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Among the group adhering to the 800-calorie food regimen, researchers discovered that “this very-low-calorie food regimen profoundly altered the intestine microbiome, together with an total lower in intestine micro organism,” defined Peter Turnbaugh, Ph.D., an affiliate professor of microbiology and immunology at UCSF and a senior writer on the research, in an announcement.
Fecal samples from research topics have been then transplanted into mice raised in sterile situations. What researchers found was that the mice whose transplants included samples of dieter’s post-calorie-restriction fecal micro organism misplaced weight. The major distinction between the intestine micro organism of these on the food regimen and those that weren’t? The quantity of C. difficile, a bacterium that’s related to diarrhea and irritation of the digestive tract.
Shutterstock”Ordinarily we’d predict elevated irritation and even colitis following a rise in C. difficile,” defined Turnbaugh. In this case, nonetheless, the mice with elevated C. difficile counts confirmed solely a light improve in irritation.
While Turnbaugh defined that the research’s findings under no circumstances recommend that the voluntary introduction of C. difficile ought to change into a go-to technique for weight reduction, he famous that the stunning findings definitely advantage additional research.
“We wish to higher perceive how frequent weight reduction diets may influence and the microbiome and what the downstream penalties are for well being and illness,” stated Turnbaugh of the research’s outcomes.
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